Kalpa Pharmaceuticals Primoxyl (Methenolone Acetate, 50 pills x 25 mg) is an oral anabolic steroid widely known as oral Primobolan. Primobolan is the trade name for the anabolic steroid Methenolone (also written as Metenolone). Should to be mentioned, Primobolan is available in both an injectable oil-based format, as well as an oral form. The oral format is known as Methenolone Acetate. It is a very well-known and popular anabolic steroid due to its very mild nature as both an anabolic and an androgenic compound. It is often compared to Anavar, a similar anabolic steroid but the difference between the two is very distinct – Anavar possesses a far greater anabolic strength rating than Primo. Primobolan is actually a very weak anabolic steroid, weaker in fact, than Testosterone itself. It possesses an anabolic rating of 88, while Testosterone’s anabolic strength rating is 100 – this demonstrates Primobolan’s fairly weak strength in terms of anabolic capabilities. The same holds true for its androgenic strength rating, which is approximately 44 – 57 in comparison with Testosterone’s androgenic rating of 100. This weaker androgenic strength rating is actually very favorable, but its weak anabolic strength capability leaves it as a far less desired anabolic steroid where the majority of individuals considering its use often opt for Anavar instead. It is instead utilized as primarily a compound in cutting cycles, whereby the preservation of muscle mass is the goal instead of the addition of new mass. Along this same line of logic, this anabolic is almost never utilized in bulking cycles due to its lack in anabolic strength.
Primobolan’s properties and details were first released and published in 1960. Squibb released the injectable format of Primobolan (Methenolone Enanthate) first in 1962 followed by the release of the oral variant of Primo (Methenolone Acetate) into the American market in the same year. It was at the time marketed under the brand name Nibal Depot (for the injectable) and Nibal for the oral variant dosed at 20mg per tablet. Very shortly afterwards, the rights for manufacture of the compound were sold in West Germany to Schering. Following this sale of rights, Nibal was removed from the US market and instead, Schering marketed the compound under the new trade name Primobolan (for both variants). It then became the quintessential anabolic steroid manufactured by Schering, who then marketed the compound as an internationally exclusive drug, and would never return to the American Market. An interesting point to note is that even though Primobolan was never marketed in the United States after Schering had bought the rights to it, it is still listed as an FDA approved drug. This had enabled American doctors to be able to import it on special order.
Like most anabolic steroids at the time, in the early 1990s it was eventually pulled from all markets and Schering ceased production as a result of the increasingly growing mass hysteria surrounding anabolic steroids and the growing anti-steroid sentiment in the media of the time.
As far as the oral variant is concerned (Methenolone Acetate), it too was pulled from the majority of markets and ceased production as well. However, pharmaceutical grade oral Primo can be located in Japan and South Africa and India.
The oral format of Primobolan holds an Acetate ester chemically bonded to it, which is attached to the 17-beta-hydroxyl group on the chemical structure. This allows the oral anabolic steroid to be resistant to oxidation and hepatic breakdown through oral administration. The oral form of Primobolan has demonstrated effective oral bioavailability in studies as both in its Acetate format as well as its un-esterified format. Esterification will now be explained in more detail.
Primobolan being a DHT-derivative, it holds many of the same properties of its parent hormone. For example its not aromatized by the aromatase enzyme into Estrogen at any dose. Therefore, any individual looking to utilize it should never experience any Estrogen related side effects from using it alone. This means that it completely avoids the potential for any of the following side effects: water retention and bloating, elevated blood pressure (as a result of water retention), possible fat gain/retention, and gynecomastia. Without the puffy and soft look that aromatizable anabolic steroids provide the physique, Primobolan is regarded by the majority of bodybuilders and athletes as a preferred ‘cutting’ compound considered very useful for pre-contest cycles and fat loss and cutting phases.
Unfortunately, because of its poor anabolic strength rating making it lower in strength than Testosterone, Primobolan is not preferred by athletes or bodybuilders for bulking cycles, lean mass cycles, or for any measurable strength gain. Primo is also best combined with (stacked with) other anabolic steroids as well, whether utilizing it for a cutting cycle or a bulking or lean mass cycle. The use of Primobolan solitarily on its own is regarded by many as a near useless practice, and along these same lines, many anabolic steroid users claim that Primo is only useful at very high doses, which may not be very practical considering the high cost of this anabolic steroid. This dosing information will be further expanded in the doses section of this profile.
The first thing to understand with Primobolan is that it is a DHT-derivative, meaning it is a modified form of DHT (Dihydrotestosterone). As such, it carries with it many similar properties and characteristics, including the inability to convert (aromatize) into Estrogen at any dose used. This should certainly be a comforting fact to most individuals who are concerned about Estrogenic side effects, such as bloating, gynecomastia, high blood pressure as a result of water retention, etc.
Although the oral format of Primobolan is C-17 Alpha Alkylated (also known as Methylation), which is a process that tends to make oral compounds present a degree of harm to the liver, Primobolan has never shown any measurable hepatotoxic effects to the body. Although oral Primo does not impose any measurable negative effects on the liver, it still presents some small amount of hepatotoxicity and this should still be understood, especially when it comes to extended cycle lengths and/or very high dosages. With that being said, one death of an anemic patient who was prescribed oral Primobolan has been linked to its use. Once again, high doses and/or very long cycle lengths of oral Primobolan may be a concern.
As much as Primobolan is touted by athletes and bodybuilders as being a ‘mild’ anabolic steroid, it still exhibits suppression of endogenous Testosterone production and HPTA function. In fact, studies have confirmed that at even a very low dosage (30 – 45mg daily), test subjects experienced 15 – 65% suppression of natural endogenous Testosterone production. Being that those dosages as far lower than what is required for performance enhancement purposes, it is still heavily recommended to perform a proper PCT (Post Cycle Therapy) following the discontinuation of Primobolan.
Primobolan cycles are commonly in the form of fat loss and/or cutting cycles. It is almost never used as a bulking or mass-gaining agent, and most of its use is in the form of a pre-contest drug in the final weeks leading up to a competition show or photo shoot. It is typically cycled with other compounds that hold similar qualities, properties, and half-lives. Many bodybuilders often stack Primobolan with Testosterone Propionate (or Testosterone Enanthate) and use it for the first 8 weeks of a cycle in order to assist in the retention of muscle mass during periods of low caloric intake.
Other bodybuilders will perform oral Primobolan cycles stacked with compounds such as Testosterone Propionate and Trenbolone Acetate, as all of the compounds involved work synergistically especially where half-lived are concerned. Some may opt to use Primobolan (either the oral or injectable) with some form of Testosterone and Winstrol (Stanozolol), typically the injectable form if it is with the oral Primobolan. It is important to remember not to utilize two different oral compounds within the same cycle.
Oral Primobolan (Methenolone Acetate) should normally be run for no longer than 8 weeks, and the injectable form (Methenolone Enanthate) can be run in cycle lengths of 10 – 12 weeks (or longer, depending on the individual’s goals and desires).
Primobolan dosage and administration depends heavily upon which form is being used: oral or injectable. Medical prescription Primobolan dosages outline 200mg as a first dosage, followed with 100mg every week for the complete duration of therapy. The medical condition being treated would determine what the actual full Primobolan dosage is. The range can be anywhere from 100mg every one or two weeks to 200mg every two to three weeks. Medical guidelines for oral Primobolan dosages call for 100 – 150mg per day for no longer than 6 – 8 weeks of consistent use.
Oral Primobolan dosages begin in the range of 50 – 100mg per day for beginners, 100 – 150mg per day for intermediates, and 150 – 200mg for advanced users. Female oral Primobolan dosages are usually recommended to be within the range of 50 – 70mg per day, and should present little risk of virilization.
Oral Primo should be administered once per day with no requirement to split up dosages throughout the day, as its half-life is about 2 – 3 days.
Men 50-100 mg/day, Women 10-25 mg/day
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